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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1B
All Species:
13.03
Human Site:
T166
Identified Species:
23.89
UniProt:
Q5I0G3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5I0G3
NP_001034934.1
518
58651
T166
M
H
T
E
I
S
I
T
L
F
D
N
K
Q
A
Chimpanzee
Pan troglodytes
XP_001138429
518
58619
T166
M
H
T
E
I
S
I
T
L
F
D
N
K
Q
A
Rhesus Macaque
Macaca mulatta
XP_001106735
518
58711
T166
M
H
T
E
I
S
I
T
L
F
D
N
K
Q
A
Dog
Lupus familis
XP_536042
532
60173
N166
M
H
T
E
I
S
L
N
L
F
D
N
K
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q5F204
500
56279
T166
M
H
T
E
I
S
L
T
L
F
D
Q
E
Q
R
Rat
Rattus norvegicus
O88989
334
36465
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508036
548
61874
H158
M
E
T
E
I
S
I
H
L
L
D
S
H
R
Y
Chicken
Gallus gallus
Q5ZME2
334
36525
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q08BZ4
447
50254
C118
N
Q
A
T
K
E
L
C
M
E
E
E
V
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394487
333
36140
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001201789
553
61629
R160
H
D
N
E
V
S
I
R
L
L
T
K
P
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
95.9
77.2
N.A.
69.1
20.6
N.A.
55.8
20.2
N.A.
39.9
N.A.
N.A.
20.2
N.A.
36.8
Protein Similarity:
100
99.6
97.4
87.9
N.A.
82.8
35.5
N.A.
72.4
33.9
N.A.
58.4
N.A.
N.A.
38.4
N.A.
55.1
P-Site Identity:
100
100
100
80
N.A.
73.3
0
N.A.
53.3
0
N.A.
0
N.A.
N.A.
0
N.A.
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
0
N.A.
66.6
0
N.A.
20
N.A.
N.A.
0
N.A.
40
Percent
Protein Identity:
N.A.
21.8
N.A.
21.2
N.A.
N.A.
Protein Similarity:
N.A.
35.7
N.A.
35.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
31
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
47
0
0
0
8
% D
% Glu:
0
8
0
54
0
8
0
0
0
8
8
8
8
16
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
39
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
39
0
0
0
0
0
8
0
0
0
0
8
8
0
% H
% Ile:
0
0
0
0
47
0
39
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
8
31
0
0
% K
% Leu:
0
0
0
0
0
0
24
0
54
16
0
0
0
0
0
% L
% Met:
47
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
0
8
0
0
0
0
8
0
0
0
31
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
8
0
31
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
16
% R
% Ser:
0
0
0
0
0
54
0
0
0
0
0
8
0
0
0
% S
% Thr:
0
0
47
8
0
0
0
31
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _